INCLUSION COMPOUNDS OF LANKACIDIN-GROUP ANTIBIOTICS WITH CYCLODEXTRINS

Abstract

Lankacidin-group antibiotics formed inclusion compounds with β-cyclodextrin in molar ratios of about 1:1. These compounds showed remarkably improved water-solubility and stability in aqueous solutions. The structure of the inclusion compounds of lankacidin A is proposed based on the facility of their inclusion with β-cyclodextrin and the results of ₁H NMR spectral studies.