SAQUAYAMYCINS, NEW AQUAYAMYCIN-GROUP ANTIBIOTICS

TAKESHI UCHIDA; MASAYA IMOTO; YOSHINOWRI WATANABE; KEIKO MIURA; TOSHIKO DOBASHI; NAOKO MATSUDA; TSUTOMU SAWA; HIROSHI NAGANAWA; MASA HAMADA; TOMIO TAKEUCHI; HAMAO UMEZAWA

doi:10.7164/antibiotics.38.1171

TAKESHI UCHIDA, MASAYA IMOTO, YOSHINOWRI WATANABE, KEIKO MIURA, TOSHIKO DOBASHI, NAOKO MATSUDA, TSUTOMU SAWA, HIROSHI NAGANAWA, MASA HAMADA, TOMIO TAKEUCHI, HAMAO UMEZAWA

Author information

TAKESHI UCHIDA
Institute of Microbial Chemistry
MASAYA IMOTO
Institute of Microbial Chemistry
YOSHINOWRI WATANABE
Institute of Microbial Chemistry
KEIKO MIURA
Institute of Microbial Chemistry
TOSHIKO DOBASHI
Institute of Microbial Chemistry
NAOKO MATSUDA
Institute of Microbial Chemistry
TSUTOMU SAWA
Institute of Microbial Chemistry
HIROSHI NAGANAWA
Institute of Microbial Chemistry
MASA HAMADA
Institute of Microbial Chemistry
TOMIO TAKEUCHI
Institute of Microbial Chemistry
HAMAO UMEZAWA
Institute of Microbial Chemistry

JOURNAL FREE ACCESS

1985 Volume 38 Issue 9 Pages 1171-1181

DOI https://doi.org/10.7164/antibiotics.38.1171

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Abstract

From the culture broth ofStreptomyces nodosus MH190-16F3, four new antibiotics have been isolated, and named saquayamycins A, B, C and D. The compounds are glycosides of aquayamycin, and among aquayamycin-group antibiotics they are most closely related to P-1894B (vineomycin A₁). All saquayamycins act on Gram-positive bacteria and inhibit the growth of adriamycin-sensitive and adriamycin-resistant P388 leukemia cells.

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