The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
PRODUCTION OF NANAOMYCIN AND OTHER ANTIBIOTICS BY PHOSPHATE-DEPRESSED FERMENTATION USING PHOSPHATE-TRAPPING AGENTS
ROKURO MASUMAYOSHITAKE TANAKAHAJIME TANAKASATOSHI OMURA
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1986 Volume 39 Issue 11 Pages 1557-1564

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Abstract

Nanaomycin production by Streptanyces rosa subsp. notoensis in complex media was inhibited by exogenously supplied inorganic phosphate. The inhibition was reversed by phosphate-trapping agents such as allophane and aluminum oxide. Under such condition nanaomycin production increased to the control level, and the phosphate content dropped down to the unsupplemented level. When allophane was added to conventional complex media containing nutrient-derived inorganic phosphate, the production of nanaomycin and several other antibiotics, which are subject to phosphate regulation, was enhanced several fold with the simultaneous reduction of free phosphate. The term "phosphate-depressed fermentation" is proposed for this technique.

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© Japan Antibiotics Research Association
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