1986 Volume 39 Issue 4 Pages 575-580
Oral administration of forphenicinol, S-2-(3-hydroxy-4- hydroxymethylphenyl)glycine, increased the production of la-positive peritoneal macrophages in healthy mice. Moreover, forphenicinol increased la-positive macrophages in L1210-bearing mice. Though forphenicinol was ineffective against mouse leukemia L1210 when administered alone, in combination with L1210 vaccine it prolonged the survival time of 1, 1210-bearing mice and the increase in the number of la-positive macrophages in peritoneal cavity coincided with the prolongation of the survival time. These results suggest that the initial action of forphenicinol is the preferential induction of la-positive macrophages, which play a role in the subsequent activation of various immune responses including macrophage activation.
