The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
THERAPEUTIC EFFECT OF SF-2103A, A NOVEL CARBAPENEM ANTIBIOTIC, IN COMBINATION WITH CEFOTAXIME, CEFOPERAZONE AND OTHER CEPHALOSPORINS
TAKASHI YOSHIDAYUZO KAZUNOTOMOKO SHOMURASHINJIRO MURATASHIGEHARU INOUYETATSUO ITO
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1986 Volume 39 Issue 7 Pages 956-965

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Abstract

Combinations of SF-2103A with cefotaxime, cefoperazone or cefazolin showed synergistic efficacy at a wide range of combination ratios against experimental infection in mice due to Proteus vulgaris GN76/C-1, producing type Ic cephalosporinase, Escherichia coli No. 29/36 RGN823, producing type IIIa (TEM-2) penicillinase and E. coli GN206, producing type Ib cephalosporinase. These effects by SF-2103A were greater than those seen with sulbactam. The in vitro and in vivo synergistic activities were roughly correlated. Potent in vivo activity of SF-2103A was related to good pharmacokinetic properties, with blood half-life of 30 minutes and urinary recovery of 55.2% after parenteral administration to rats. Furthermore, SF-2103A was stable to rat kidney homogenate. The high stability of SF-2103A in aqueous and biological media was correlated with the sulfonate group at C-3.

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© Japan Antibiotics Research Association
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