ENZYMATIC CONVERSION OF 7-HYDROXYGUANINE TO ITS NUCLEOSIDES

MIKIO KITAHARA; KIYOTO ISHII; TAKESHI OKAZAKI; TAKAYOSHI HIDAKA; KIYOSHI WATANABE

doi:10.7164/antibiotics.39.1288

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

ENZYMATIC CONVERSION OF 7-HYDROXYGUANINE TO ITS NUCLEOSIDES

MIKIO KITAHARA, KIYOTO ISHII, TAKESHI OKAZAKI, TAKAYOSHI HIDAKA, KIYOSHI WATANABE

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JOURNAL FREE ACCESS

1986 Volume 39 Issue 9 Pages 1288-1290

DOI https://doi.org/10.7164/antibiotics.39.1288

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Abstract

7-Hydroxyguanine, an antitumor purine-analog, reacted with ribose (or deoxyribose)-1-phosphate in the presence of purine nucleoside phosphorylase. We prepared 7-hydroxyguanine riboside and deoxyriboside using purine nucleoside phosphorylase from bovine spleen. Each nucleoside exhibits antitumor activity against mouse leukemia L1210 cells. The therapeutic effect of 7-hydroxyguanine deoxyriboside is superior to those of 7-hydroxyguanine and 7-hydroxyguanine riboside.

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