IDENTIFICATION OF NOVEL ERYTHROMYCIN DERIVATIVES IN MOTHER LIQUOR CONCENTRATES OF STREPTOMYCES ERYTHRAEUS

ISAAC O. KIBWAGE; GERARD JANSSEN; ROGER BUSSON; Jos HOOGMARTENS; HUBERT VANDERHAEGHE; LUDO VERBIST

doi:10.7164/antibiotics.40.1

IDENTIFICATION OF NOVEL ERYTHROMYCIN DERIVATIVES IN MOTHER LIQUOR CONCENTRATES OF STREPTOMYCES ERYTHRAEUS

ISAAC O. KIBWAGE, GERARD JANSSEN, ROGER BUSSON, Jos HOOGMARTENS, HUBERT VANDERHAEGHE, LUDO VERBIST

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JOURNAL FREE ACCESS

1987 Volume 40 Issue 1 Pages 1-6

DOI https://doi.org/10.7164/antibiotics.40.1

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Abstract

The identification of five novel compounds, pseudo-erythromycin A-6, 9-hemiketal, 8, 9-anhydro-pseudo-erythromycin A-6, 9-hemiketal, 8, 9-anhydro-pseudo-N-demethylery thromycin A-6, 9-hemiketal, 5-O-β-D-desosaminylerythronolide A and 15-nor-erythromycin C, in mother liquor concentrates of Streptomyces erythraeus is described. The pseudo-erythromycin derivatives are characterized by a 12-membered macrocyclic ring as a result of C₁₃→C₁₁ trans-lactonization. The five compounds have very little antimicrobial activity.

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