STUDIES ON WF-3681, A NOVEL ALDOSE REDUCTASE INHIBITOR I. TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION

MOTOAKI NISHIKAWA; YASUHISA TSURUMI; TAKAYUKI NAMIKI; KEIZO YOSHIDA; MASAKUNI OKUHARA

doi:10.7164/antibiotics.40.1394

STUDIES ON WF-3681, A NOVEL ALDOSE REDUCTASE INHIBITOR

I. TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION

MOTOAKI NISHIKAWA, YASUHISA TSURUMI, TAKAYUKI NAMIKI, KEIZO YOSHIDA, MASAKUNI OKUHARA

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JOURNAL FREE ACCESS

1987 Volume 40 Issue 10 Pages 1394-1399

DOI https://doi.org/10.7164/antibiotics.40.1394

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Abstract

WF-3681 was isolated from a cultured filtrate of Chaetomella raphigera as a novel inhibitor of aldose reductase. It was extracted with ethyl acetate and then purified with silica gel chromatography. Its molecular formula was determined to be C₁₃H₁₂O₅ by elemental analysis and high resolution electron impact mass spectrometry. IC₅₀ of WF-3681 was 2.5×10^-7 M for partially purified aldose reductase of rabbit lens.

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