A NOVEL TETRACYCLINE FROM ACTINOMADURA BRUNNEA FERMENTATION, ISOLATION AND STRUCTURE ELUCIDATION

MAHESH PATEL; VINCENT P. GULLO; VINOD R. HEGDE; ANN C. HORAN; FRANK GENTILE; JOSEPH A. MARQUEZ; GEORGE H. MILLER; MOHINDAR S. PUAR; J. ALLAN WAITZ

doi:10.7164/antibiotics.40.1408

A NOVEL TETRACYCLINE FROM ACTINOMADURA BRUNNEA

FERMENTATION, ISOLATION AND STRUCTURE ELUCIDATION

MAHESH PATEL, VINCENT P. GULLO, VINOD R. HEGDE, ANN C. HORAN, FRANK GENTILE, JOSEPH A. MARQUEZ, GEORGE H. MILLER, MOHINDAR S. PUAR, J. ALLAN WAITZ

Author information

MAHESH PATEL
Department of Microbial Products, Sobering Corporation
VINCENT P. GULLO
Department of Microbial Products, Sobering Corporation
VINOD R. HEGDE
Department of Microbial Products, Sobering Corporation
ANN C. HORAN
Department of Microbial Products, Sobering Corporation
FRANK GENTILE
Department of Microbial Products, Sobering Corporation
JOSEPH A. MARQUEZ
Department of Microbial Products, Sobering Corporation
GEORGE H. MILLER
Department of Microbial Products, Sobering Corporation
MOHINDAR S. PUAR
Department of Microbial Products, Sobering Corporation
J. ALLAN WAITZ
Department of Microbial Products, Sobering Corporation

JOURNAL FREE ACCESS

1987 Volume 40 Issue 10 Pages 1408-1413

DOI https://doi.org/10.7164/antibiotics.40.1408

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Abstract

A novel tetracycline antibiotic, Sch 33256, was isolated from a culture broth of a new species of Actinomadura. The antibiotic was isolated by solvent extraction, Sephadex G-25 column chromatography and crystallization. The structure was determined by comparison of the spectra with that of chlortetracycline. Spectroscopic analysis of the compound yielded 2'-N-methyl-8-methoxychlortetracycline as the proposed structure.

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