The Journal of Antibiotics
AMINOTHIAZOLYLGLYCYL DERIVATIVES OF CARBACEPHEM ANTIBIOTICS
II. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NOVEL AMINOTHIAZOLYL CEPHEM COMPOUNDS WITH HYDROXYPYRIDONE MOIETY
KENICHI MOCHIDAYASUYUKI ONOMOTOO YAMASAKICHIHIRO SHIRAKITADASHI HIRATAKIYOSHI SATORYO OKACHI
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Volume 40 (1987) Issue 2 Pages 182-189

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Abstract

The synthesis and antimicrobial activity of novel carbacephem antibiotics which have amido moiety of (S)-aminothiazolylglycyl side chain are described. Among them, the compound having 5-hydroxy-4-pyridon-2-carboxyl group (KT-4697) showed exceptionally strong activity against Pseudomonas aeruginosa as well as Gram-negative bacteria. A cephalosporin with this acyl group namely KT-4788 with methylpyridiniumthiomethyl group at C-3 was found to be the most active against Gram-positive and Gram-negative strains including P. aeruginosa.

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