The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
ENZYMATIC PHOSPHORYLATION OF MACROLIDE ANTIBIOTICS
PAUL F. WILEY, LUBOMIR BACZYNSKYJ, LESTER A. DOLAK, JOYCE I. CIALDELLA, VINCENT P. MARSHALL
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JOURNAL FREE ACCESS

1987 Volume 40 Issue 2 Pages 195-201

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Abstract

Five macrolide antibiotics (erythromycin A, 1; oleandomycin, 3a; tylosin, 4a; spiramycins, 5a; leucomycin A3, 6a) have been phosphorylated enzymatically using cell-free extracts derived from Streptomyces coelicolor UC 5240. The necessary cofactors and the rates of the conversion have been determined.

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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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