7-HYDRO-8-METHYLPTEROYLGLUTAMYLGLUTAMIC ACID, A NEW ANTI-FOLATE FROM AN ACTINOMYCETE FERMENTATION, ISOLATION, STRUCTURE AND BIOLOGICAL ACTIVITY

MASATSUNE MURATA; HARUO TANAKA; SATOSHI OMURA

doi:10.7164/antibiotics.40.251

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

7-HYDRO-8-METHYLPTEROYLGLUTAMYLGLUTAMIC ACID, A NEW ANTI-FOLATE FROM AN ACTINOMYCETE

FERMENTATION, ISOLATION, STRUCTURE AND BIOLOGICAL ACTIVITY

MASATSUNE MURATA, HARUO TANAKA, SATOSHI OMURA

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JOURNAL FREE ACCESS

1987 Volume 40 Issue 3 Pages 251-257

DOI https://doi.org/10.7164/antibiotics.40.251

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Abstract

A new anti-folate, 7-hydro-8-methylpteroylglutamylglutamic acid, was isolated from the culture broth of a soil actinomycete. The antibiotic inhibited the growth of Enterococcus faecium which requires folic acid. The inhibitory action was reversed by thymidine or excess amounts of folate-related compounds such as pteroic acid, folic acid, dihydrofolic acid and leucovorin. It inhibited thymidylate synthase from E. faecium, Bacillus subtilis and Ehrlich ascites carcinoma cells.

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