The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ANTIBIOTICS FROM BASIDIOMYCETES. 26
PHLEBIAKAURANOL ALDEHYDE AN ANTIFUNGAL AND CYTOTOXIC METABOLITE FROM PUNCTULARIA ATROPURPURASCENS
H. ANKEI. CASSERW. STEGLICHE.-H. POMMER
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1987 Volume 40 Issue 4 Pages 443-449

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Abstract

Phlebiakauranol aldehyde and the corresponding alcohol were isolated from cultures of Punctularia atropurpurascens. The aldehyde but not the alcohol exhibited strong antifungal activity against several phytopathogens as well as antibacterial and cytotoxic activities. Two acetylated derivatives prepared from the aldehyde showed only very weak antifungal and antibacterial and moderate cytotoxic activities. We therefore assume, that the aldehyde group together with the high number of hydroxyl groups are responsible for the biological activity of the compound.

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