MODIFICATION OF THE CYSTEAMINE SIDE CHAIN OF THIENAMYCIN. II

MAKOTO SATO; MAKOTO TAKEMURA; SHOHGO ATARASHI; KUNIO HIGASHI; HIROYUKI FUJIWARA; TAKAYASU NAGAHARA; MINORU FURUKAWA; TORU IKEUCHI; SEIICHI OZAWA; NOBUKO NISHIZAWA; YASUAKI OSADA

doi:10.7164/antibiotics.40.483

MAKOTO SATO, MAKOTO TAKEMURA, SHOHGO ATARASHI, KUNIO HIGASHI, HIROYUKI FUJIWARA, TAKAYASU NAGAHARA, MINORU FURUKAWA, TORU IKEUCHI, SEIICHI OZAWA, NOBUKO NISHIZAWA, YASUAKI OSADA

Author information

MAKOTO SATO
Laboratory of Medicinal Chemistry
MAKOTO TAKEMURA
Laboratory of Medicinal Chemistry
SHOHGO ATARASHI
Laboratory of Medicinal Chemistry
KUNIO HIGASHI
Laboratory of Medicinal Chemistry
HIROYUKI FUJIWARA
Laboratory of Medicinal Chemistry
TAKAYASU NAGAHARA
Laboratory of Medicinal Chemistry
MINORU FURUKAWA
Laboratory of Medicinal Chemistry
TORU IKEUCHI
Laboratory of Microbiology & Pathology, Research Institute, Daiichi Seiyaku Co., Ltd.
SEIICHI OZAWA
Laboratory of Microbiology & Pathology, Research Institute, Daiichi Seiyaku Co., Ltd.
NOBUKO NISHIZAWA
Laboratory of Microbiology & Pathology, Research Institute, Daiichi Seiyaku Co., Ltd.
YASUAKI OSADA
Laboratory of Microbiology & Pathology, Research Institute, Daiichi Seiyaku Co., Ltd.

JOURNALS FREE ACCESS

Volume 40 (1987) Issue 4 Pages 483-495

DOI https://doi.org/10.7164/antibiotics.40.483

Details

Abstract

A new type of thienamycin derivatives (3a-3j, 4a, 4b), having a monothioacetal or a thioacetal side chain at the C-2 position was prepared, and the susceptibility to renal dehydropeptidase-1 (DHP-1) and the antimicrobial activity of these compounds were determined. The structure-activity relationships of these derivatives are also discussed.

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