STRUCTURE OF A NOVEL Ca²⁺ AND CALMODULIN-DEPENDENT CYCLIC NUCLEOTIDE PHOSPHODIESTERASE INHIBITOR K-259-2

Abstract

The structure of K-259-2, a potent inhibitor of Ca²⁺ and calrnodulin-dependent cyclic nucleotide phosphodiesterase, was determined to be 3-(2Z-2-ethyl-2-butenyl)-l, 6, 8-trihydroxyanthraquinone-2-carboxylic acid by chemical conversion and spectral studies.