The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
FK-506, A NOVEL IMMUNOSUPPRESSANT ISOLATED FROM A STREPTOMYCES
II. IMMUNOSUPPRESSIVE EFFECT OF FK-506 IN VITRO
TORU KINO, HIROSHI HATANAKA, SUSUMU MIYATA, NORIAKI INAMURA, MICHIHISA NISHIYAMA, TOSHIMI YAJIMA, TOSHIO GOTO, MASAKUNI OKUHARA, MASANOBU KOHSAKA, HATSUO AOKI, TAKENORI OCHIAI
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1987 Volume 40 Issue 9 Pages 1256-1265

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Abstract

The immuno-pharmacological profile of a novel immunosuppressive agent, FK-506 produced by a streptomycete, is presented here. We proceeded to test the effect of the agent on various in vitro immune systems. It showed that mixed lymphocyte reaction, cytotoxic T cell generation, the production of T cell-derived soluble mediators such as interleukin 2 (IL-2), interleukin 3 and gamma-interferon and the expression of the IL-2 receptor were suppressed by this agent. The IC50 values of FK-506 and ciclosporin (CS) in all tests were approximately 0.1nM and 10nM, respectively. Therefore, the novel agent, FK-506 suppressed in vitro immune systems at about hundred times lower concentration than CS.

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The Journal of Antibiotics, Series A

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