ARUGOMYCIN, A NEW ANTHRACYCLINE ANTIBIOTIC I. TAXONOMY, FERMENTATION, ISOLATION AND PHYSICO-CHEMICAL PROPERTIES

HIROYUKI KAWAI; YOICHI HAYAKAWA; MASAYA NAKAGAWA; KAZUO FURIHATA; KEIKO FURIHATA; AKIRA SHIMAZU; HARUO SETO; NOBORU OTAKE

doi:10.7164/antibiotics.40.1266

ARUGOMYCIN, A NEW ANTHRACYCLINE ANTIBIOTIC

I. TAXONOMY, FERMENTATION, ISOLATION AND PHYSICO-CHEMICAL PROPERTIES

HIROYUKI KAWAI, YOICHI HAYAKAWA, MASAYA NAKAGAWA, KAZUO FURIHATA, KEIKO FURIHATA, AKIRA SHIMAZU, HARUO SETO, NOBORU OTAKE

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JOURNAL FREE ACCESS

1987 Volume 40 Issue 9 Pages 1266-1272

DOI https://doi.org/10.7164/antibiotics.40.1266

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Abstract

Arugomycin (AGM) is a new anthracycline antibiotic produced by strain No. 1098-(Vsb2)AV2 which was identified as Streptomyces violaceochromogenes. AGM was isolated by solvent extraction, silicic acid chromatography and Sephadex LH-20 column chromatography. Acid treatment of AGM gave the chromophore, named arugorol, which was identified as 4'-epi-nogalarol, and sugar moieties. AGM inhibited the growth of Gram-positive bacteria and showed antitumor activity against sarcoma S-180 and Ehrlich ascites tumors.

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