MODIFICATION OF THE CYSTEAMINE SIDE CHAIN OF THIENAMYCIN. Ill

MAKOTO SATO; MAKOTO TAKEMURA; SHOHGO ATARASHI; KUNIO HIGASHI; TAKAYASU NAGAHARA; MINORU FURUKAWA; TORU IKEUCHI; YASUAKI OSADA

doi:10.7164/antibiotics.40.1292

MAKOTO SATO, MAKOTO TAKEMURA, SHOHGO ATARASHI, KUNIO HIGASHI, TAKAYASU NAGAHARA, MINORU FURUKAWA, TORU IKEUCHI, YASUAKI OSADA

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JOURNALS FREE ACCESS

Volume 40 (1987) Issue 9 Pages 1292-1302

DOI https://doi.org/10.7164/antibiotics.40.1292

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Abstract

Thienamycin derivatives (4) having a cyclic amidine moiety at the C-2 position were prepared. The susceptibility to renal dehydropeptidase-1 and the antimicrobial activity of these compounds were determined. Their structure-activity relationships are also discussed.

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