Sch 37137, A NOVEL ANTIFUNGAL COMPOUND PRODUCED BY A MICROMONOSPORA SP. TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE AND BIOLOGICAL PROPERTIES

RAYMOND COOPER; ANN C. HORAN; FRANK GENTILE; VINCENT GULLO; DAVID LOEBENBERG; JOSEPH MARQUEZ; MAHESH PATEL; MOHINDAR S. PUAR; IMBI TRUUMEES

doi:10.7164/antibiotics.41.13

Sch 37137, A NOVEL ANTIFUNGAL COMPOUND PRODUCED BY A MICROMONOSPORA SP.

TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE AND BIOLOGICAL PROPERTIES

RAYMOND COOPER, ANN C. HORAN, FRANK GENTILE, VINCENT GULLO, DAVID LOEBENBERG, JOSEPH MARQUEZ, MAHESH PATEL, MOHINDAR S. PUAR, IMBI TRUUMEES

Author information

RAYMOND COOPER
Pharmaceutical Research Division, Schering Plough Corporation
ANN C. HORAN
Pharmaceutical Research Division, Schering Plough Corporation
FRANK GENTILE
Pharmaceutical Research Division, Schering Plough Corporation
VINCENT GULLO
Pharmaceutical Research Division, Schering Plough Corporation
DAVID LOEBENBERG
Pharmaceutical Research Division, Schering Plough Corporation
JOSEPH MARQUEZ
Pharmaceutical Research Division, Schering Plough Corporation
MAHESH PATEL
Pharmaceutical Research Division, Schering Plough Corporation
MOHINDAR S. PUAR
Pharmaceutical Research Division, Schering Plough Corporation
IMBI TRUUMEES
Pharmaceutical Research Division, Schering Plough Corporation

JOURNAL FREE ACCESS

1988 Volume 41 Issue 1 Pages 13-19

DOI https://doi.org/10.7164/antibiotics.41.13

Details

Abstract

A new antifungal compound, Sch 37137, was isolated from the cultured broth of a Micromonospora sp., SCC 1792. Sch 37137 is structurally related to A 19009, a dipeptide previously discovered from a Streptomyces sp. The compound was weakly active against species of Candida and dermatophytes (mean MICs ≥128μg/ml) in Sabouraud dextrose, yeastnitrogen and modified Eagles minimum essential media; however activity against Candida sp. (mean MICs ≥12μg/ml) and dermatophytes (mean MICs ≥0.8μg/ml) significantly improved in MA medium.

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