The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
POROTHRAMYCIN, A NEW ANTIBIOTIC OF THE ANTHRAMYCIN GROUP: PRODUCTION, ISOLATION, STRUCTURE AND BIOLOGICAL ACTIVITY
MITSUAKI TSUNAKAWAHIDEO KAMEIMASATAKA KONISHITAKEO MIYAKITOSHIKAZU OKIHIROSHI KAWAGUCHI
Author information
JOURNAL FREE ACCESS

1988 Volume 41 Issue 10 Pages 1366-1373

Details
Abstract

A new antitumor antibiotic porothramycin was produced by a new strain of Streptomyces albus1, 2). The antibiotic was isolated in two active forms, the natural free hydroxyl form (porothramycin A) or the crystalline methyl ether form (porothramycin B) depending upon the isolation process used. Structural studies established that porothramycin is a new member of the pyrrolo[1, 4]benzodiazepine group antibiotics having only one substituent on the benzene ring. The antibiotic exhibited antimicrobial activity against Gram-positive bacteria and anaerobes and significantly prolonged the survival times of mice implanted with experimental tumors.

Content from these authors
© Japan Antibiotics Research Association
Previous article Next article
feedback
Top