The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
A NEW MACROMOLECULAR ANTITUMOR ANTIBIOTIC, C-1027
I. DISCOVERY, TAXONOMY OF PRODUCING ORGANISM, FERMENTATION AND BIOLOGICAL ACTIVITY
JILAN HUYU-CHUAN XUEMEI-YU XIERUI ZHANGTOSHIO OTANIYOSHINORI MINAMIYUJI YAMADATERUYOSHI MARUNAKA
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1988 Volume 41 Issue 11 Pages 1575-1579

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Abstract

Strain C-1027, an actinomycete isolated from a soil sample collected in China, was found to produce the new antibiotic, C-1027. From taxonomical studies on its morphological, cultural and physiological characteristics, this antibiotic-producing strain was identified as Streptomyces ghbisporus C-1027. Antibiotic C-1027 has antimicrobial activity against most Gram-positive bacteria but not against Mycobacterium sp. or Gram-negative bacteria. This antibiotic shows remarkable activity in spermatogonial assay and potent cytotoxicity against KB carcinoma cells in vitro, and exhibits inhibition on transplantable tumors in mice.

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© Japan Antibiotics Research Association
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