NEW ANTIBIOTICS 4181-A AND B FROM STREPTOMYCES GRISEUS; TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION

TOSHIO OTANI; ICHIRO YAMAWAKI; HIROSHI MATSUMOTO; YOSHINORI MLNAMI; YUJI YAMADA; TERUYOSHI MARUNAKA; CHANG-QING Qi; TIE TIAN; Rui ZHANG; MEI-YU XIE; JING-RONG Lu

doi:10.7164/antibiotics.41.275

NEW ANTIBIOTICS 4181-A AND B FROM STREPTOMYCES GRISEUS; TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION

TOSHIO OTANI, ICHIRO YAMAWAKI, HIROSHI MATSUMOTO, YOSHINORI MLNAMI, YUJI YAMADA, TERUYOSHI MARUNAKA, CHANG-QING Qi, TIE TIAN, Rui ZHANG, MEI-YU XIE, JING-RONG Lu

Author information

TOSHIO OTANI
Biological Research Laboratory, Taiho Pharmaceutical Co., Ltd.
ICHIRO YAMAWAKI
Biological Research Laboratory, Taiho Pharmaceutical Co., Ltd.
HIROSHI MATSUMOTO
Biological Research Laboratory, Taiho Pharmaceutical Co., Ltd.
YOSHINORI MLNAMI
Biological Research Laboratory, Taiho Pharmaceutical Co., Ltd.
YUJI YAMADA
Biological Research Laboratory, Taiho Pharmaceutical Co., Ltd.
TERUYOSHI MARUNAKA
Biological Research Laboratory, Taiho Pharmaceutical Co., Ltd.
CHANG-QING Qi
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences
TIE TIAN
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences
Rui ZHANG
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences
MEI-YU XIE
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences
JING-RONG Lu
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences

JOURNAL FREE ACCESS

1988 Volume 41 Issue 3 Pages 275-281

DOI https://doi.org/10.7164/antibiotics.41.275

Details

Abstract

The new antibiotics 4181-A and B were isolated from the fermentation broth of Streptomyces griseus, a soil isolate. Their molecular formulae were determined as C₂₉H₂₁NO₉ and C₂₈H₁₉NO₉, respectively. The UV, IR and NMR spectra suggest that they possess a quinone moiety in their structures. They were found to have antibacterial, antifungal and antitumor activity.

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