1988 Volume 41 Issue 4 Pages 530-537
1-N-(D-Threo-3-amino-2-hydroxybutanoyl)-2', 3'-dideoxykanamycin A has been prepared by coupling of 3, 6'-bis(N-benzyloxycarbony-2', 3'-dideoxy-3''-N-(trifluoroacetyl)kanamycin A with D-threo-3-azido-2-hydroxybutanoic acid. A diastereomeric mixture of the erythro analog has also been prepared by use of racemic erythro-3-azido-2-hydroxybutanoic acid. Synthesis of the D-threo- and racemic erythro-3-amino-2-hydroxybutanoic acids has been described.