The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
14-HYDROXY-6-O-METHYLERYTHROMYCINS A, ACTIVE METABOLITES OF 6-O-METHYLERYTHROMYCIN A IN HUMAN
TAKASHI ADACHISHIGEO MORIMOTOHIDEAKI KONDOHTAKATOSHI NAGATEYOSHIAKI WATANABEKAORU SOTA
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1988 Volume 41 Issue 7 Pages 966-975

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Abstract

(14R)-14-Hydroxy-6-O-methylerythromycin A and (14S)-epimer have been isolated as active metabolites from human urine after oral administration of 6-O-methylerythromycin A (TE-031, A-56268). The structures of these metabolites were determined by means of mass, 1H and 13C NMR spectroscopies. Antimicrobial activities of (14R)-14-hydroxy-6-O-methylerythromycin A, a major metabolite, were comparable to those of the parent drug TE-031, whereas (14S)-14-hydroxy-6-O-methylerythromycin A was 4- to 8-fold less active than TE-031 against bacterial standard strains.

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© Japan Antibiotics Research Association
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