The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
BIOLOGICAL ACTIVITIES OF DEOXYSPERGUALIN IN AUTOIMMUNE DISEASE MICE
KYUICHI NEMOTOMICHIKO HAYASHIYUMI SUGAWARAJUNPEI ITOFUMINORI ABETOMOHISA TAKITATERUYA NAKAMURATOMIO TAKEUCHI
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Volume 41 (1988) Issue 9 Pages 1253-1259

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Abstract

An assessment of the prophylactic and ameliorative effects of deoxyspergualin (NKT-01), an immunosuppressive agent, was carried out in male MRL/MpJ-1pr/1pr (MRL/1) mice which spontaneously develop lupus-like lesions. When NKT-01 was administered ip daily from the age of either 8 or 19 weeks, diseases such as massive lymphadenopathy, circulating anti-DNA antibody and lupus nephritis were markedly suppressed. The primary response to lipopolysaccharide was significantly reduced in MRL/1 mice administered NKT-01 but the response to sheep red blood cells was not affected. The ability of spleen cells to release interleukins 2 and 3 with or without mitogen was significantly enhanced in mice receiving NKT-01. These findings demonstrate that NKT-01 has therapeutic activity against the development of spontaneous disease in MRL/1 mice.

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