The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
EPIDERSTATIN, A NEW INHIBITOR OF THE MITOGENIC ACTIVITY INDUCED BY EPIDERMAL GROWTH FACTOR
II. STRUCTURE ELUCIDATION
TADAMICHI SONODAHIROYUKI OSADAMASAKAZU URAMOTOJUN UZAWAKIYOSHI ISONO
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JOURNAL FREE ACCESS

1989 Volume 42 Issue 11 Pages 1607-1609

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Abstract
The structure of a novel antibiotic, epiderstatin, was determined as 4-[3-((Z)-3, 5-dimethyl-2-oxopiperidin-6-ylidene)-2-oxopropyl]-2, 6-piperidinedione by spectroscopic analyses of 1H NMR, 13C NMR, 1H-1H correlation spectroscopy (COSY), 13C-1H COSY, heteronuclear multiple bond correlation spectroscopy, UV and IR spectra. The antibiotic belongs to the glutarimide antibiotics, however, the characteristic feature of epiderstatin is that it has a piperidone ring instead of a cyclohexanone ring.
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© Japan Antibiotics Research Association
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