The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
LEINAMYCIN, A NEW ANTITUMOR ANTIBIOTIC FROM STREPTOMYCES; PRODUCING ORGANISM, FERMENTATION AND ISOLATION
MITSUNOBU KARAKOZO ASANOISAO KAWAMOTOTOSHIMITSU TAKIOUCHISHIGEO KATSUMATAKEI-ICHI TAKAHASHIHIROFUMI NAKANO
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1989 Volume 42 Issue 12 Pages 1768-1774

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Abstract

Leinamycin (DC 107) is newly discovered antitumor antibiotic with an unusual 1, 3-dioxo-1, 2-dithiolane structure. Five different producing strains were isolated from soils collected in Japan during 1985 - 1988 and were taxonomically assigned as Streptomyces. Fermentation studies indicate: Leinamycin was unstable in culture broth. A chemically defined medium could be designed for a preferable production. Streptomyces sp. S-140 grew on medium supplemented with Zn2+ and high porus polymer resin and accumulated 32μg/ml of leinamycin. Improved isolation methods are described along with identification of mikamycin A co-produced with leinamycin by the strain S-140.

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© Japan Antibiotics Research Association
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