MYROCIN C, A NEW DITERPENE ANTITUMOR ANTIBIOTIC FROM MYROTHECIUM VERRUCARIA II. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE DETERMINATION

YUAN-HSUN HSU; AKIRA HIROTA; SHOJI SHIMA; MASAHIRA NAKAGAWA; TOMOHIRO ADACHI; HIROSHI NOZAKI; MITSURU NAKAYAMA

doi:10.7164/antibiotics.42.223

MYROCIN C, A NEW DITERPENE ANTITUMOR ANTIBIOTIC FROM MYROTHECIUM VERRUCARIA

II. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE DETERMINATION

YUAN-HSUN HSU, AKIRA HIROTA, SHOJI SHIMA, MASAHIRA NAKAGAWA, TOMOHIRO ADACHI, HIROSHI NOZAKI, MITSURU NAKAYAMA

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JOURNAL FREE ACCESS

1989 Volume 42 Issue 2 Pages 223-229

DOI https://doi.org/10.7164/antibiotics.42.223

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Abstract

The structure of a new antitumor antibiotic, myrocin C, from a strain of Myrothecium vermcaria was characterized as a pentacyclic pimarane diterpene composed of a γ-lactol group and a unique cyclopropane ring on the basis of its physico-chemical properties and spectroscopic data as well as a single-crystal X-ray diffraction analysis of its monoacetyl derivative.

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