RAMOPLANIN (A-16686), A NEW GLYCOLIPODEPSIPEPTIDE ANTIBIOTIC

III. STRUCTURE ELUCIDATION

Abstract

By combination of chemical, ¹H and ¹³C NMR, and mass spectrometric studies, the structures of the three components of the antibiotic ramoplanin (A-16686), produced by Actinoplanes sp. ATCC 33076, have been elucidated. All the components have structures formed by a common depsipeptide skeleton carrying a dimannosyl group and are differentiated by the presence of various acylamide moieties, derived from C₈, C₉ and C₁₀ fatty acids.