RAMOPLANIN (A-16686), A NEW GLYCOLIPODEPSIPEPTIDE ANTIBIOTIC IV. COMPLETE SEQUENCE DETERMINATION BY HOMONUCLEAR 2D NMR SPECTROSCOPY

J. K. KETTENRING; R. CIABATTI; G. WINTERS; G. TAMBORINI; B. CAVALLERI

doi:10.7164/antibiotics.42.268

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

RAMOPLANIN (A-16686), A NEW GLYCOLIPODEPSIPEPTIDE ANTIBIOTIC

IV. COMPLETE SEQUENCE DETERMINATION BY HOMONUCLEAR 2D NMR SPECTROSCOPY

J. K. KETTENRING, R. CIABATTI, G. WINTERS, G. TAMBORINI, B. CAVALLERI

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JOURNAL FREE ACCESS

1989 Volume 42 Issue 2 Pages 268-275

DOI https://doi.org/10.7164/antibiotics.42.268

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Abstract

Homonuclear 2D NMR spectroscopy double quantum filter correlation spectroscopy (DQF-COSY), relayed-COSY, nuclear Overhauser enhancement spectroscopy (NOESY), and DQF-relayed-NOESY) allowed the complete determination of the core depsipeptide of antibiotic ramoplanin (A-16686). In particular, the DQF-relayed-NOESY experiments were essential in assigning the single signals close to the diagonal.

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