SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NOVEL 3-SUBSTITUTED CARBACEPHEMS

Abstract

A series of novel 3-heterocyclothio substituted carbacephems having phenylglycyl side chain have been prepared starting from 3-H carbacephem. The compounds exhibit better chemical stability than the corresponding cephalosporin and strong activity against Gramnegative and Gram-positive organisms including Enterococcus faecalis.