The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
DEACETYLRAVIDOMYCIN N-OXIDE, A NEW ANTIBIOTIC TAXONOMY AND FERMENTATION OF THE PRODUCING ORGANISM AND ISOLATION, STRUCTURE AND BIOLOGICAL PROPERTIES OF THE ANTIBIOTIC
TADASHI NARITAMASARU MATSUMOTOKINICHI MOGIKEN-ICHI KUKITARYUICHI KAWAHARATOSHIAKI NAKASHIMA
Author information
JOURNAL FREE ACCESS

1989 Volume 42 Issue 3 Pages 347-356

Details
Abstract

Streptomyces ravidus S50905 was found to produce a new antibiotic, deacetylravidomycin N-oxide, together with ravidomycin and deacetylravidomycin in a culture medium containing sodium anthraquinone-β-sulfonate. The structure of this new compound was determined from NMR and mass spectrometric data, and further confirmed by chemical synthesis from deacetylravidomycin.
Deacetylravidomycin N-oxide was antitumor active against P388 leukemia and Meth A fibrosarcoma in a wide range of doses, and considerably less toxic than deacetylravidomycin. Its antibacterial activity was less potent than deacetylravidomycin. Ravidomycin N-oxide was also synthesized from ravidomycin and its biological properties were tested.

Content from these authors
© Japan Antibiotics Research Association
Next article
feedback
Top