A NEW ANTITUMOR ANTIBIOTIC, FR900840 I. DISCOVERY, IDENTIFICATION, ISOLATION AND CHARACTERIZATION

MAKOTO NISHIMURA; HIROHISA NAKADA; HIDENORI NAKAJIMA; YASUHIRO HORI; MASAMI EZAKI; TOSHIO GOTO; MASAKUNI OKUHARA

doi:10.7164/antibiotics.42.542

A NEW ANTITUMOR ANTIBIOTIC, FR900840

I. DISCOVERY, IDENTIFICATION, ISOLATION AND CHARACTERIZATION

MAKOTO NISHIMURA, HIROHISA NAKADA, HIDENORI NAKAJIMA, YASUHIRO HORI, MASAMI EZAKI, TOSHIO GOTO, MASAKUNI OKUHARA

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JOURNAL FREE ACCESS

1989 Volume 42 Issue 4 Pages 542-548

DOI https://doi.org/10.7164/antibiotics.42.542

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Abstract

A new antitumor antibiotic, FR900840, was isolated from a culture broth of Streptomyces strain No. 8727 as a pale yellowish prism and the molecular formula was determined to be C₇H₁₁N₃O₅. The antibiotic exhibited prominent antitumor effects on human tumor cell lines both in vitro and in vivo.

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