The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS-ASSOCIATED REVERSE TRANSCRIPTASE BY 14-O-ACYLADRIAMYCINS
KEIICHI AJITO, SONOKO ATSUMI, DAISHIRO IKEDA, SHINICHI KONDO, TOMIO TAKEUCHI, KAZUO UMEZAWA
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1989 Volume 42 Issue 4 Pages 611-619

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Abstract

It was reported that doxorubicin inhibited virus reverse transcriptase. We have synthesized various new 14-O-acyladriamycins. The derivatives having a 14-O-benzoyl group with hydrophobic aliphatic side chains showed stronger inhibitory activity on human immunodeficiency virus reverse transcriptase and lower cytotoxicity on mouse leukemia cells.

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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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