NEW GLUTARIMIDE ANTIBIOTICS, S-632-B₁ AND B₂

II. ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND CHEMICAL STRUCTURE

Abstract

Antifungal antibiotics S-632-A₁, A₂, B₁ and B₂ were extracted with ethyl acetate from the filtered broth of Streptomyces hygroscopicus S-632 and isolated through a combination of conventional and reversed-phase silica gel column chromatography. On the basis of the spectral data, S-632-B₁ and B₂ were found to be new members of the glutarimide family of antibiotics. The chemical structures of these components were elucidated as two stereoisomers of 3-(5, 7-dimethyl-8, 9-epoxy-2-hydroxy-4-oxo-6-decenyl)glutarimide.