LANTHIOPEPTIN, A NEW PEPTIDE ANTIBIOTIC PRODUCTION, ISOLATION AND PROPERTIES OF LANTHIOPEPTIN

NOBUAKI NARUSE; OSAMU TENMYO; KOJI TOMITA; MASATAKA KONISHI; TAKEO MIYAKI; HIROSHI KAWAGUCHI; KOICHI FUKASE; TATEAKI WAKAMIYA; TETSUO SHIBA

doi:10.7164/antibiotics.42.837

LANTHIOPEPTIN, A NEW PEPTIDE ANTIBIOTIC

PRODUCTION, ISOLATION AND PROPERTIES OF LANTHIOPEPTIN

NOBUAKI NARUSE, OSAMU TENMYO, KOJI TOMITA, MASATAKA KONISHI, TAKEO MIYAKI, HIROSHI KAWAGUCHI, KOICHI FUKASE, TATEAKI WAKAMIYA, TETSUO SHIBA

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JOURNAL FREE ACCESS

1989 Volume 42 Issue 6 Pages 837-845

DOI https://doi.org/10.7164/antibiotics.42.837

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Abstract

A strain of Streptoverticillium dnnamoneum produced a peptide antibiotic named lanthiopeptin, which contained four unusual amino acids, erythro-β-hydroxyaspartic acid, meso-lanthionine, threo-β-methyllanthionine and lysinoalanine. Lanthiopeptin showed antiviral activity against herpes simplex virus type 1 KOS strain infection in Vero cells by cytopathic effect reduction assay. The structure of lanthiopeptin is similar to that of ancovenin.

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