ORALLY ABSORBABLE D-FORPHENICINOL-CEPHALOSPORINS

YOSHIYUKI KOYAMA; SHYH-PYNG HUANG; DAISHIRO IKEDA; MASA HAMADA; SHINICHI KONDO; TOMIO TAKEUCHI

doi:10.7164/antibiotics.42.993

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

ORALLY ABSORBABLE D-FORPHENICINOL-CEPHALOSPORINS

YOSHIYUKI KOYAMA, SHYH-PYNG HUANG, DAISHIRO IKEDA, MASA HAMADA, SHINICHI KONDO, TOMIO TAKEUCHI

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JOURNAL FREE ACCESS

1989 Volume 42 Issue 6 Pages 993-999

DOI https://doi.org/10.7164/antibiotics.42.993

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Abstract

The synthesis and biological evaluation of D-forphenicinol-cephalosporins are described. 7-Amino-3-(substituted)-3-cephem-4-carboxylic acid esters were coupled with N-tert-butoxycarbonyl-D-forphenicinol derivatives. Most of cephalosporin analogs in this series had good antibacterial activities and were well absorbed from the gastrointestinal tract in mice. Among them, 7-(mono-O-methyl-D-forphenicinol)-3-propenyl analog showed the most significant result in biological evaluations.

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