The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
SELECTION OF A SPECIFICALLY BLOCKED MUTANT OF STREPTOMYCES CINNAMONENSIS: ISOLATION AND SYNTHESIS OF 26-DEOXYMONENSIN A
DOREEN M. ASHWORTHDUNCAN S. HOLMESJOHN A. ROBINSONHIDEAKI OIKAWADAVID E. CANE
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1989 Volume 42 Issue 7 Pages 1088-1099

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Abstract

Streptomyces cinnamonensis produces the polyether ionophore antibiotic monensin A. Following a single round of mutagenesis by UV light, a derivative of this strain has been isolated, which secretes a new metabolite identified as 26-deoxymonensin A (3). The structural elucidation of the new metabolite followed from a spectroscopic analysis, and its identity was proven conclusively following a comparison to 26-deoxymonensin A (3) obtained synthetically from monensin A. The preparation of labelled forms of 3 is described, together with incorporation experiments using the parent strain of S. cinnamonensis. Only very low levels of incorporation of 3 into monensin A were observed.

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© Japan Antibiotics Research Association
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