The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ANTIBIOTICS FROM BASIDIOMYCETES
XXXVII. NEW INHIBITORS OF CHOLESTEROL BIOSYNTHESIS FROM CULTURES OF XERULA MELANOTRICHA DÖRFELT
DOROTHÉE KUHNTTIMM ANKEHELMUT BESLMONIKA BROSSRUPERT HERRMANNURSULA MOCEKBERT STEFFANWOLFGANG STEGLICH
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1990 Volume 43 Issue 11 Pages 1413-1420

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Abstract

Three new inhibitors of cholesterol biosynthesis have been isolated from cultures of Xerula melanotricha and their structures elucidated by spectroscopic methods. Dihydroxerulin (1) in admixture with xerulin (2) strongly inhibits the incorporation of 14C- acetate into cholesterol in HeLa cells while the incorporation of 14C-mevalonate is not affected. Xerulinic acid (3) shows similar biological activities but a higher cytotoxicity.

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