J-STAGE Home  >  Publications - Top  > Bibliographic Information

The Journal of Antibiotics
Vol. 43 (1990) No. 12 P 1586-1589

Language:

http://doi.org/10.7164/antibiotics.43.1586


We have screened toyocamycin as an inhibitor of phosphatidylinositol kinase. It inhibited the enzyme of A431 cell membrane with an IC50 of 3.3 μg/ml. Adenosine and formycin A also inhibited the enzyme, but other 6 related nucleosides did not. Although orobol and 2, 3-dihydroxybenzaldehyde that inhibit phosphatidylinositol kinase inhibited in situ phosphatidylinositol turnover, toyocamycin did not.

Copyright © Japan Antibiotics Research Association

Article Tools

Share this Article