The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
FR112123, A NEW OLIGOPEPTIDE ANTIBIOTIC FROM STREPTOMYCES VIRIDOCHROMOGENES
TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES, STRUCTURE AND BIOLOGICAL ACTIVITY
AKIHIKO FUJIETOSHIRO IWAMOTONOBUHARU SHIGEMATSUMASAMI EZAKIMOTOHIRO HINOSEIJI HASHIMOTOMASAKUNI OKUHARAMASANOBU KOHSAKAHIROSHI IMANAKA
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1990 Volume 43 Issue 5 Pages 449-455

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Abstract

FR112123 is a new oligopeptide antibiotic produced by Streptomyces viridochromogenes No. 7587. The structure of FR112123 is elucidated as N-(N6-(N2-glycyl-L-glutaminyl)-D-lysyl)-D-alanine (1) by spectroscopic and chemical evidence. It resembles a partial structure of peptidoglycan in bacteria. The compound has a superior activity against an Escherichia coli mutant sensitive to inhibitors of cell wall synthesis, although it has a weak activity against the parent strain. These suggest that FR112123 might act on the biosynthesis of bacterial cell wall.

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© Japan Antibiotics Research Association
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