SIMAOMICIN (LL-D42067), A NOVEL ANTIBIOTIC FROM ACTINOMADURA MADURAE

I. TAXONOMY, FERMENTATION AND BIOLOGICAL ACTIVITY

Abstract

A new antibacterial antibiotic, designated simaomicin α (LL-D42067 α) was isolated from the fermentation broth of an actinomycete strain. Based on cultural, physiological, morphological and chemical characteristics, culture LL-D42067 was identified as a new subspecies of Actinomadura madurae. Simaomicin α demonstrated potent activity against Gram-positive bacteria and was active in vivo against a variety of Eimeria species causing coccidiosis in chickens.