AMPHOTERICIN B O-METHYL OXIME SYNTHESIS AND BIOLOGICAL PROPERTIES

ANDRZEJ CZERWINSKI; WILFRIED A. KÖNIG; PAWEL SOWINSKI; LEONARD FALKOWSKI; JAN MAZERSKI; EDWARD BOROWSKI

doi:10.7164/antibiotics.43.1098

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

AMPHOTERICIN B O-METHYL OXIME SYNTHESIS AND BIOLOGICAL PROPERTIES

ANDRZEJ CZERWINSKI, WILFRIED A. KÖNIG, PAWEL SOWINSKI, LEONARD FALKOWSKI, JAN MAZERSKI, EDWARD BOROWSKI

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JOURNAL FREE ACCESS

1990 Volume 43 Issue 9 Pages 1098-1100

DOI https://doi.org/10.7164/antibiotics.43.1098

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Abstract

Synthesis and biological properties of amphotericin B O-methyl oxime are described. The presence of an intact hemiketal ring in the antibiotic molecule appeared to be essential for its biological activity.

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