The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
SYNTHESIS AND BIOLOGICAL ACTIVITY OF 3-VINYLTHIO-AND 3-VINYLTHIOMETHYLCEPHEM DERIVATIVES
SHINTARO NISHIMURANOBUYOSHI YASUDAHIROSHI SASAKIKOHJI KAWABATAKAZUO SAKANETAKAO TAKAYA
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1990 Volume 43 Issue 9 Pages 1160-1168

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Abstract

The synthesis and biological properties of some 3-vinylthio- and 3-vinylthiomethylcephem derivatives are described. Both series possess potent antibacterial activity. Among them, 3-[(Z)-2-cyanovinylthiomethyl]cephem derivative was found to have an expanded antibacterial spectrum.

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© Japan Antibiotics Research Association
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