ANTHRACYCLINE METABOLITES FROM Streptomyces violaceous A262

II. NEW ANTHRACYCLINE EPELMYCINS PRODUCED BY A BLOCKED MUTANT STRAIN SU2-730

Abstract

New anthracycline antibiotics, identified as ε-rhodomycinone glycosides, were isolated from the culture broth of a blocked mutant of β-rhodomycin-producing Streptomyces violaceus A262. They were designated as epelmycins A, B, C, D and E, and assayed for their in vitro cytotoxicities against murine leukemic L1210 cell culture and the antimicrobial activities in comparison with known anthracycline antibiotics.