ANTIFUNGAL AND ANTIVIRAL ACTIVITIES OF BENANOMICINS AND THEIR ANALOGUES

SHINICHI KONDO; SHUICHI GOMI; DAISHIRO IKEDA; MASA HAMADA; TOMIO TAKEUCHI; HIDEAKI IWAI; JUN-ICHI SEKI; HIROO HOSHINO

doi:10.7164/antibiotics.44.1228

SHINICHI KONDO, SHUICHI GOMI, DAISHIRO IKEDA, MASA HAMADA, TOMIO TAKEUCHI, HIDEAKI IWAI, JUN-ICHI SEKI, HIROO HOSHINO

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JOURNAL FREE ACCESS

1991 Volume 44 Issue 11 Pages 1228-1236

DOI https://doi.org/10.7164/antibiotics.44.1228

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Abstract

In vitro activities of benanomicins and their analogues against human immunodeficiency virus and fungi including Candida, Cryptococcus and Aspergillus, were examined. The free carboxyl group and at least one sugar moiety in the benanomicins were essential for their activities. Benanomicin A was most active and had low toxicity, and was selected as the best candidate for chemotherapy.

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