DUNAIMYCINS, A NEW COMPLEX OF SPIROKETAL 24-MEMBERED MACROLIDES WITH IMMUNOSUPPRESSIVE ACTIVITY I. TAXONOMY OF THE PRODUCING ORGANISMS, FERMENTATION AND ANTIMICROBIAL ACTIVITY

JAMES P. KARWOWSKI; MARIANNA JACKSON; MARY L. MAUS; WILLIAM L. KOHL; PATRICK E. HUMPHREY; PAULINE M. TILLIS

doi:10.7164/antibiotics.44.1312

DUNAIMYCINS, A NEW COMPLEX OF SPIROKETAL 24-MEMBERED MACROLIDES WITH IMMUNOSUPPRESSIVE ACTIVITY

I. TAXONOMY OF THE PRODUCING ORGANISMS, FERMENTATION AND ANTIMICROBIAL ACTIVITY

JAMES P. KARWOWSKI, MARIANNA JACKSON, MARY L. MAUS, WILLIAM L. KOHL, PATRICK E. HUMPHREY, PAULINE M. TILLIS

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JOURNAL FREE ACCESS

1991 Volume 44 Issue 12 Pages 1312-1317

DOI https://doi.org/10.7164/antibiotics.44.1312

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Abstract

The dunaimycins are a new complex of spiroketal 24-membered macrolides discovered in the fermentation broth of two actinomycetes. Based on taxonomic studies these two cultures, which were isolated from soil, were identified as Streptomyces diastatochromogenes strains AB 1691Q-321 and AB 1711J-452. The dunaimycins possess both immunosuppressive and antimicrobial activity.

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