The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
ENDOTHELIN-BINDING INHIBITORS, BE-18257A AND BE-18257B
I. TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION
KATSUHISA KOJIRIMASAKI IHARASHIGERU NAKAJIMAKENJI KAWAMURAKOHTARO FUNAISHIMITSUO YANOHIROYUKI SUDA
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1991 Volume 44 Issue 12 Pages 1342-1347

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Abstract

Two endothelin (ET)-binding inhibitors, BE-18257A and BE-18257B, which antagonized 125I-ET-1 binding to a porcine aortic smooth muscle membrane, were isolated from the mycelium of a strain of Streptomyces misakiensis. These binding inhibitors were extracted with methanol from mycelium and purified by HPLC.

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© Japan Antibiotics Research Association
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