The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
WF-2421, A NEW ALDOSE REDUCTASE INHIBITOR PRODUCED FROM A FUNGUS, Humicola grisea
MOTOAKI NISHIKAWAYASUHISA TSURUMIHIDETSUGU MURAIKEIZO YOSHIDAMASANORI OKAMOTOSHIGEHIRO TAKASEHIROKAZU TANAKAHIROSHI HIROTAMASASHI HASHIMOTOMASANOBU KOHSAKA
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1991 Volume 44 Issue 2 Pages 130-135

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Abstract

WF-2421 is a novel aldose reductase inhibitor produced by Humicola grisea. WF-2421 was purified from the culture filtrate by successive ion exchange chromatography and the chemical structure was assigned to be α-formamido-5'-(2-formamido-l-hydroxyethyl)-β, 2', 6-trihydroxy-3-biphenylpropanoic acid (1) on the basis of spectroscopic evidence.
The IC50 value of WF-2421 was 3 × 10-8 M against partially purified aldose reductase of rabbit lens.

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