SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NEW C-10 QUINOLONYL-CEPHEM ESTERS

THOMAS P. DEMUTH; RONALD E. WHITE; RUTH A. TIETJEN; RONALD J. STORRIN; JAMES R. SKUSTER; JON A. ANDERSEN; CHARLES C. MCOSKER; RAYMOND FREEDMAN; F. JAMES ROURKE

doi:10.7164/antibiotics.44.200

THOMAS P. DEMUTH, RONALD E. WHITE, RUTH A. TIETJEN, RONALD J. STORRIN, JAMES R. SKUSTER, JON A. ANDERSEN, CHARLES C. MCOSKER, RAYMOND FREEDMAN, F. JAMES ROURKE

Author information

THOMAS P. DEMUTH
Norwich Eaton Pharmaceuticals, Inc., a Procter & Gamble Company
RONALD E. WHITE
Norwich Eaton Pharmaceuticals, Inc., a Procter & Gamble Company
RUTH A. TIETJEN
Norwich Eaton Pharmaceuticals, Inc., a Procter & Gamble Company
RONALD J. STORRIN
Norwich Eaton Pharmaceuticals, Inc., a Procter & Gamble Company
JAMES R. SKUSTER
Norwich Eaton Pharmaceuticals, Inc., a Procter & Gamble Company
JON A. ANDERSEN
Norwich Eaton Pharmaceuticals, Inc., a Procter & Gamble Company
CHARLES C. MCOSKER
Norwich Eaton Pharmaceuticals, Inc., a Procter & Gamble Company
RAYMOND FREEDMAN
Norwich Eaton Pharmaceuticals, Inc., a Procter & Gamble Company
F. JAMES ROURKE
Norwich Eaton Pharmaceuticals, Inc., a Procter & Gamble Company

JOURNAL FREE ACCESS

1991 Volume 44 Issue 2 Pages 200-209

DOI https://doi.org/10.7164/antibiotics.44.200

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Abstract

A series of cephalosporins derived from cephalothin containing an ester-linked quinolonyl substituent at the C-10 position (C-10 quinolonyl-cephem esters) has been prepared and evaluated for in vitro antibacterial activity. The C-10 quinolonyl-cephem esters exhibited a broadened spectrum of activity when compared with cephalothin and the corresponding quinolones, including activity against β-lactamase-producing bacteria.

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